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MPC-300-IV for biologic refractory rheumatoid arthritis (RA): Results of a new study were published in the peer-reviewed journal Stem Cell Research & Therapy, showing that a single intravenous infusion of 150 million of the Company's proprietary allogeneic "off-the-shelf" STRO-3 immunoselected MPCs significantly improved clinical disease severity, reduced joint cartilage erosions, and improved synovial inflammation and histopathology in a large animal model of early RA. This study provides mechanistic and translational support for the clinical outcomes reported in the ongoing Phase 2 trial of MPC-300-IV for biologic refractory RA. Recent results from this 48-patient placebo-controlled, randomized Phase 2 trial evaluating two dosing regimens against placebo in RA patients resistant to anti-Tumor Necrosis Factor (TNF) agents showed that a single intravenous infusion of MPC-300-IV resulted in durable responses through nine months (39 weeks). All three cohorts were well matched for disease activity and other demographics at baseline. The results showed that: - The safety profile over 39 weeks was comparable among the placebo and both MPC treatment groups, with no cell-related serious adverse events. - Both MPC doses outperformed placebo at week 39 in each of ACR20/50/70 responses, as well as by median ACR-N analysis. - Continuous variables ACR-N, HAQ-DI and DAS-28 were used in line with the FDA Guidance For Industry Rheumatoid Arthritis: Developing Drug Products For Treatment, May 2013, and identified the 2 million MPC/kg dose as the most effective over 39 weeks. - The 2 million MPC/kg dose showed the earliest and most sustained treatment benefit. - The RA population resistant to anti-TNF agents constitutes about one-third of patients treated with these agents, is the fastest growing branded market segment within the $19 billion global RA biologics market, and is set to grow further as multiple anti-TNF biosimilars become available; the goal of therapy in these patients is to achieve early and sustained low disease activity which correlates with prevention of structural joint damage in RA. Given doctor home mortgage loan Oak Laurel 0430129662 oaklaurel.com.au the serious nature of anti-TNF resistant RA, MPC-300-IV is well-positioned to be developed as a regenerative advanced therapy to target this major unmet medical need.